Drug interactions
Olanzapine + Tacrolimus
Severity: Moderate
Olanzapine and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have been linked to QT prolongation, so together they may raise the risk of arrhythmia. Tacrolimus can also cause electrolyte disturbances such as hypomagnesemia and hyperkalemia that add to the risk.
What this interaction means in plain words
Olanzapine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QT prolongation, with tacrolimus-related electrolyte changes contributing.
What to do
Obtain a baseline ECG and monitor QTc, magnesium and potassium during combined therapy. Replace electrolytes as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Olanzapine with Tacrolimus?
MediHelp rates the interaction as moderate. Olanzapine and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have been linked to QT prolongation, so together they may raise the risk of arrhythmia. Tacrolimus can also cause electrolyte disturbances such as hypomagnesemia and hyperkalemia that add to the risk.
How serious is the interaction between Olanzapine and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, magnesium and potassium during combined therapy. Replace electrolytes as needed.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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