Drug interactions
Olanzapine + Vorinostat
Severity: Moderate
Olanzapine and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat can prolong the QT interval, and olanzapine may add a modest effect. Patients with electrolyte disturbances or heart disease are at higher risk of arrhythmia.
What this interaction means in plain words
Olanzapine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc periodically during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Olanzapine with Vorinostat?
MediHelp rates the interaction as moderate. Olanzapine and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat can prolong the QT interval, and olanzapine may add a modest effect. Patients with electrolyte disturbances or heart disease are at higher risk of arrhythmia.
How serious is the interaction between Olanzapine and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc periodically during co-therapy.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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