Drug interactions
Olanzapine + Zolmitriptan
Severity: Minor
Olanzapine and Zolmitriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptans have been reported to contribute to serotonin syndrome with other serotonergic drugs, and olanzapine has some serotonergic receptor activity. Clinically significant interaction appears uncommon but is possible.
What this interaction means in plain words
Olanzapine and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olanzapine belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects; the mechanism is not firmly established.
What to do
The combination can generally be used with patient counseling on symptoms of serotonin toxicity such as agitation, tremor, fever and diarrhea. Stop the triptan and treat if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olanzapine
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Olanzapine with Zolmitriptan?
MediHelp rates the interaction as minor. Olanzapine and Zolmitriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triptans have been reported to contribute to serotonin syndrome with other serotonergic drugs, and olanzapine has some serotonergic receptor activity. Clinically significant interaction appears uncommon but is possible.
How serious is the interaction between Olanzapine and Zolmitriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can generally be used with patient counseling on symptoms of serotonin toxicity such as agitation, tremor, fever and diarrhea. Stop the triptan and treat if these occur.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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