Drug interactions
Olanzapine / samidorphan + Solifenacin
Severity: Moderate
Olanzapine / samidorphan and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic activity that adds to that of solifenacin and may cause severe constipation, ileus and urinary retention. Cognitive impairment and tachycardia may also be worsened.
What this interaction means in plain words
Olanzapine / samidorphan and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects reducing gastrointestinal and urinary tract motility.
What to do
Monitor bowel function and urinary symptoms, use a bowel regimen where appropriate, and reduce or stop solifenacin if constipation or retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Olanzapine / samidorphan with Solifenacin?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic activity that adds to that of solifenacin and may cause severe constipation, ileus and urinary retention. Cognitive impairment and tachycardia may also be worsened.
How serious is the interaction between Olanzapine / samidorphan and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms, use a bowel regimen where appropriate, and reduce or stop solifenacin if constipation or retention develops.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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