Drug interactions
Olanzapine / samidorphan + Tapentadol
Severity: Contraindicated
Olanzapine / samidorphan and Tapentadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Samidorphan blocks opioid receptors and can reduce tapentadol's analgesic effect. In opioid-dependent patients it may precipitate acute withdrawal.
What this interaction means in plain words
Olanzapine / samidorphan and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Samidorphan antagonizes mu-opioid receptors, opposing the opioid action of tapentadol.
What to do
Avoid the combination; observe the labeled opioid-free interval (7 days for short-acting, 14 days for long-acting opioids) before starting. Use non-opioid analgesia during treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine / samidorphan and Tapentadol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
- Procarbazine + Tapentadol Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Tapentadol?
MediHelp rates the interaction as contraindicated. Olanzapine / samidorphan and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors and can reduce tapentadol's analgesic effect. In opioid-dependent patients it may precipitate acute withdrawal.
How serious is the interaction between Olanzapine / samidorphan and Tapentadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; observe the labeled opioid-free interval (7 days for short-acting, 14 days for long-acting opioids) before starting. Use non-opioid analgesia during treatment.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
