Drug interactions
Procarbazine + Tapentadol
Severity: Contraindicated
Procarbazine and Tapentadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO inhibiting properties, so with tapentadol it may cause hypertensive reactions, serotonin toxicity and CNS excitation or depression. Tapentadol labeling advises against use with MAO inhibitors.
What this interaction means in plain words
Procarbazine and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Tapentadol belongs to Musculoskeletal.
Why it happens
Procarbazine's weak MAO inhibition combined with tapentadol's norepinephrine reuptake inhibition raises monoamine levels.
What to do
Avoid the combination, and do not give tapentadol within 14 days of procarbazine. Use an alternative analgesic and monitor blood pressure and mental status if exposure is unavoidable.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Tapentadol?
MediHelp rates the interaction as contraindicated. Procarbazine and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO inhibiting properties, so with tapentadol it may cause hypertensive reactions, serotonin toxicity and CNS excitation or depression. Tapentadol labeling advises against use with MAO inhibitors.
How serious is the interaction between Procarbazine and Tapentadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, and do not give tapentadol within 14 days of procarbazine. Use an alternative analgesic and monitor blood pressure and mental status if exposure is unavoidable.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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