Drug interactions
Linezolid + Tapentadol
Severity: Contraindicated
Linezolid and Tapentadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid is a reversible non-selective MAO inhibitor, and with tapentadol it can lead to serotonin syndrome or excessive noradrenergic stimulation including hypertensive reactions. Tapentadol labeling prohibits use with MAO inhibitors.
What this interaction means in plain words
Linezolid and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Linezolid belongs to Anti Bacterial; Tapentadol belongs to Musculoskeletal.
Why it happens
MAO inhibition by linezolid plus tapentadol's norepinephrine reuptake inhibition increases monoamine levels.
What to do
Avoid the combination and use an alternative analgesic or antibiotic. If linezolid is essential, stop tapentadol and monitor closely for serotonin toxicity and blood pressure changes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
- Procarbazine + Tapentadol Contraindicated
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Linezolid with Tapentadol?
MediHelp rates the interaction as contraindicated. Linezolid and Tapentadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible non-selective MAO inhibitor, and with tapentadol it can lead to serotonin syndrome or excessive noradrenergic stimulation including hypertensive reactions. Tapentadol labeling prohibits use with MAO inhibitors.
How serious is the interaction between Linezolid and Tapentadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative analgesic or antibiotic. If linezolid is essential, stop tapentadol and monitor closely for serotonin toxicity and blood pressure changes.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Methylene blue. The full list is on the Tapentadol page.
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