Drug interactions
Olanzapine / samidorphan + Tramadol
Severity: Contraindicated
Olanzapine / samidorphan and Tramadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Samidorphan blocks opioid receptors and can reduce tramadol's analgesic effect. In opioid-dependent patients it may precipitate acute withdrawal.
What this interaction means in plain words
Olanzapine / samidorphan and Tramadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Samidorphan antagonizes mu-opioid receptors, opposing the opioid action of tramadol.
What to do
Avoid the combination; observe the labeled opioid-free interval (7 days for short-acting, 14 days for long-acting opioids) before starting. Use non-opioid analgesia during treatment.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
- Selegiline transdermal + Tramadol Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Tramadol?
MediHelp rates the interaction as contraindicated. Olanzapine / samidorphan and Tramadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Samidorphan blocks opioid receptors and can reduce tramadol's analgesic effect. In opioid-dependent patients it may precipitate acute withdrawal.
How serious is the interaction between Olanzapine / samidorphan and Tramadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; observe the labeled opioid-free interval (7 days for short-acting, 14 days for long-acting opioids) before starting. Use non-opioid analgesia during treatment.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Tramadol page.
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