Drug interactions
Isocarboxazid + Tramadol
Severity: Contraindicated
Isocarboxazid and Tramadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining tramadol with an irreversible MAOI can cause serotonin syndrome, seizures, severe hypertension or hypotension, and profound CNS depression. Fatal reactions have been reported with MAOIs and serotonergic opioids.
What this interaction means in plain words
Isocarboxazid and Tramadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
MAO inhibition combined with tramadol's serotonin and norepinephrine reuptake inhibition produces excessive serotonergic stimulation.
What to do
Do not co-administer, and avoid tramadol within 14 days of stopping isocarboxazid. Use a non-serotonergic analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tramadol
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
- Selegiline transdermal + Tramadol Contraindicated
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Tramadol?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Tramadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining tramadol with an irreversible MAOI can cause serotonin syndrome, seizures, severe hypertension or hypotension, and profound CNS depression. Fatal reactions have been reported with MAOIs and serotonergic opioids.
How serious is the interaction between Isocarboxazid and Tramadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and avoid tramadol within 14 days of stopping isocarboxazid. Use a non-serotonergic analgesic.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Olanzapine / samidorphan, Phenelzine, Procarbazine. The full list is on the Tramadol page.
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