Drug interactions
Procarbazine + Tramadol
Severity: Contraindicated
Procarbazine and Tramadol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting activity, and tramadol inhibits serotonin and noradrenaline reuptake, so the combination can cause serotonin syndrome. Tramadol may also lower the seizure threshold.
What this interaction means in plain words
Procarbazine and Tramadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Procarbazine belongs to Oncology; Tramadol belongs to Musculoskeletal.
Why it happens
MAO inhibition combined with tramadol's monoamine reuptake inhibition.
What to do
Avoid use during and within 14 days of MAOI therapy. Use an alternative analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
- Selegiline transdermal + Tramadol Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Tramadol?
MediHelp rates the interaction as contraindicated. Procarbazine and Tramadol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting activity, and tramadol inhibits serotonin and noradrenaline reuptake, so the combination can cause serotonin syndrome. Tramadol may also lower the seizure threshold.
How serious is the interaction between Procarbazine and Tramadol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use during and within 14 days of MAOI therapy. Use an alternative analgesic.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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