Drug reference
tramadol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (Opioids)
Mechanism of action
Non-opioid-derived synthetic opioid; centrally acting analgesic, but may act at least partially by binding to opioid mu receptors, causing inhibition of ascending pain pathways
Common side effects
- Dyspepsia
- Constipation
- Dizziness
- Somnolence
- Nausea
- Vertigo
- CNS stimulation
Contraindications
- Hypersensitivity to tramadol or opioids Known or suspected gastrointestinal obstruction, including paralytic ileus Concurrent use of monoamine oxidase inhibitors (MAOIs) or use within last 14 days Children <12 years Postoperative management in children <18 years following tonsillectomy…
Known interactions (6)
- phenelzine + tramadol Contraindicated
- bupropion + tramadol Major
- carbamazepine + tramadol Major
- fluoxetine + tramadol Major
- opioid + tramadol Major
- oxycodone + tramadol Major
Related conditions
Frequently asked questions
What drug class is tramadol?
tramadol belongs to: Musculoskeletal.
How does tramadol work?
Non-opioid-derived synthetic opioid; centrally acting analgesic, but may act at least partially by binding to opioid mu receptors, causing inhibition of ascending pain pathways
What are the common side effects of tramadol?
Dyspepsia, Constipation, Dizziness, Somnolence, Nausea, Vertigo, CNS stimulation
Which drugs interact with tramadol?
phenelzine, bupropion, carbamazepine, fluoxetine, opioid, oxycodone
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