Drug interactions
Olaparib + Ribociclib
Severity: Moderate
Olaparib and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may increase olaparib concentrations, potentially worsening anemia, neutropenia and other adverse effects.
What this interaction means in plain words
Olaparib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing olaparib metabolism.
What to do
Reduce the olaparib dose per labeling for moderate CYP3A inhibitors and monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Ribociclib?
MediHelp rates the interaction as moderate. Olaparib and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may increase olaparib concentrations, potentially worsening anemia, neutropenia and other adverse effects.
How serious is the interaction between Olaparib and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the olaparib dose per labeling for moderate CYP3A inhibitors and monitor blood counts.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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