Drug interactions
Oliceridine + Paroxetine
Severity: Major
Oliceridine and Paroxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine strongly inhibits CYP2D6, which is a main pathway for oliceridine clearance, so oliceridine exposure may rise and cause more sedation and respiratory depression. Opioids with serotonergic activity combined with an SSRI also carry a theoretical risk of serotonin syndrome.
What this interaction means in plain words
Oliceridine and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by paroxetine reduces oliceridine clearance, with additive serotonergic and CNS depressant effects.
What to do
Use lower or less frequent oliceridine doses and titrate to effect while monitoring sedation and respiratory rate. Reassess the dose if paroxetine is stopped, and watch for signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Paroxetine?
MediHelp rates the interaction as major. Oliceridine and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Paroxetine strongly inhibits CYP2D6, which is a main pathway for oliceridine clearance, so oliceridine exposure may rise and cause more sedation and respiratory depression. Opioids with serotonergic activity combined with an SSRI also carry a theoretical risk of serotonin syndrome.
How serious is the interaction between Oliceridine and Paroxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower or less frequent oliceridine doses and titrate to effect while monitoring sedation and respiratory rate. Reassess the dose if paroxetine is stopped, and watch for signs of serotonin toxicity.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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