Drug interactions
Oliceridine + Phenelzine
Severity: Major
Oliceridine and Phenelzine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity combined with an MAO inhibitor may cause serotonin syndrome, and MAOIs may also potentiate opioid CNS and respiratory depression. The reaction can be severe, with agitation, hyperthermia, clonus, hypotension or coma. Opioid labeling generally advises against use with MAOIs or within 14 days of stopping them.
What this interaction means in plain words
Oliceridine and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition combined with opioid effects increases risk of serotonin toxicity and potentiates opioid CNS and respiratory depression.
What to do
Avoid oliceridine during and for 14 days after phenelzine where possible; use an alternative analgesic. If unavoidable, use the lowest dose with close monitoring and stop oliceridine if serotonin syndrome is suspected.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Phenelzine?
MediHelp rates the interaction as major. Oliceridine and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids with serotonergic activity combined with an MAO inhibitor may cause serotonin syndrome, and MAOIs may also potentiate opioid CNS and respiratory depression. The reaction can be severe, with agitation, hyperthermia, clonus, hypotension or coma. Opioid labeling generally advises against use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Oliceridine and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oliceridine during and for 14 days after phenelzine where possible; use an alternative analgesic. If unavoidable, use the lowest dose with close monitoring and stop oliceridine if serotonin syndrome is suspected.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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