Drug interactions
Oliceridine + Quinine
Severity: Moderate
Oliceridine and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine inhibits CYP2D6 and may increase oliceridine exposure, intensifying opioid effects. This raises the risk of sedation and respiratory depression.
What this interaction means in plain words
Oliceridine and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Quinine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP2D6-mediated metabolism of oliceridine by quinine.
What to do
Monitor for sedation and respiratory depression and titrate oliceridine doses carefully, allowing longer dosing intervals if needed. Watch for opioid withdrawal or reduced effect if quinine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Quinine?
MediHelp rates the interaction as moderate. Oliceridine and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine inhibits CYP2D6 and may increase oliceridine exposure, intensifying opioid effects. This raises the risk of sedation and respiratory depression.
How serious is the interaction between Oliceridine and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and titrate oliceridine doses carefully, allowing longer dosing intervals if needed. Watch for opioid withdrawal or reduced effect if quinine is stopped.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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