Drug interactions
Oliceridine + Rasagiline
Severity: Major
Oliceridine and Rasagiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid, and opioids may precipitate serotonin syndrome or opioid toxicity when combined with MAO inhibitors. Labeling for similar opioids advises avoiding use with MAOIs or within 14 days of stopping them.
What this interaction means in plain words
Oliceridine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects and MAO-related potentiation of opioid toxicity.
What to do
Avoid oliceridine in patients taking rasagiline or within 14 days of stopping it, and choose another analgesic if possible. If unavoidable, monitor for serotonin syndrome and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Rasagiline?
MediHelp rates the interaction as major. Oliceridine and Rasagiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is an opioid, and opioids may precipitate serotonin syndrome or opioid toxicity when combined with MAO inhibitors. Labeling for similar opioids advises avoiding use with MAOIs or within 14 days of stopping them.
How serious is the interaction between Oliceridine and Rasagiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oliceridine in patients taking rasagiline or within 14 days of stopping it, and choose another analgesic if possible. If unavoidable, monitor for serotonin syndrome and respiratory depression.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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