Drug interactions
Oliceridine + Rocuronium
Severity: Moderate
Oliceridine and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is an opioid that causes sedation and respiratory depression, and combined use with a neuromuscular blocker increases the risk of hypoventilation. In anesthetic practice with controlled ventilation this is expected and manageable, but residual effects can matter after surgery.
What this interaction means in plain words
Oliceridine and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Rocuronium belongs to Musculoskeletal.
Why it happens
Additive respiratory depression from central opioid effect and peripheral paralysis of respiratory muscles.
What to do
Use only with airway control and ventilatory support, and monitor neuromuscular function and respiratory rate and oxygenation after blockade is reversed. Use the lowest effective oliceridine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rocuronium
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Rocuronium?
MediHelp rates the interaction as moderate. Oliceridine and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is an opioid that causes sedation and respiratory depression, and combined use with a neuromuscular blocker increases the risk of hypoventilation. In anesthetic practice with controlled ventilation this is expected and manageable, but residual effects can matter after surgery.
How serious is the interaction between Oliceridine and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with airway control and ventilatory support, and monitor neuromuscular function and respiratory rate and oxygenation after blockade is reversed. Use the lowest effective oliceridine dose.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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