Drug interactions
Oliceridine + Safinamide
Severity: Moderate
Oliceridine and Safinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity combined with MAO inhibitors have been associated with serotonin syndrome, and opioid labeling generally warns against MAOI use. Safinamide is a selective MAO-B inhibitor, which lowers the risk at recommended doses, but oliceridine may still add to sedation and respiratory depression.
What this interaction means in plain words
Oliceridine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Safinamide belongs to Central Nervous System.
Why it happens
MAO inhibition with possible serotonergic opioid effects and additive CNS depression.
What to do
Monitor for agitation, tremor, hyperthermia, clonus and for sedation or respiratory depression, particularly after dose changes. Choose an alternative analgesic if signs of serotonin toxicity occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Safinamide?
MediHelp rates the interaction as moderate. Oliceridine and Safinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids with serotonergic activity combined with MAO inhibitors have been associated with serotonin syndrome, and opioid labeling generally warns against MAOI use. Safinamide is a selective MAO-B inhibitor, which lowers the risk at recommended doses, but oliceridine may still add to sedation and respiratory depression.
How serious is the interaction between Oliceridine and Safinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, clonus and for sedation or respiratory depression, particularly after dose changes. Choose an alternative analgesic if signs of serotonin toxicity occur.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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