Drug interactions
Oliceridine + Selegiline
Severity: Major
Oliceridine and Selegiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity combined with MAO inhibitors may cause serotonin syndrome, and MAO inhibitors can also potentiate opioid effects including respiratory depression.
What this interaction means in plain words
Oliceridine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition combined with opioid serotonergic activity and potentiation of opioid CNS effects.
What to do
Avoid oliceridine during and within 14 days of MAO inhibitor therapy. If unavoidable, use the lowest dose and monitor for serotonin toxicity and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Selegiline?
MediHelp rates the interaction as major. Oliceridine and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids with serotonergic activity combined with MAO inhibitors may cause serotonin syndrome, and MAO inhibitors can also potentiate opioid effects including respiratory depression.
How serious is the interaction between Oliceridine and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oliceridine during and within 14 days of MAO inhibitor therapy. If unavoidable, use the lowest dose and monitor for serotonin toxicity and respiratory depression.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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