Drug interactions
Oliceridine + Tolterodine
Severity: Moderate
Oliceridine and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids slow gut motility and can cause urinary retention, and anticholinergic drugs share these effects. Together they increase the risk of severe constipation, urinary retention and paralytic ileus.
What this interaction means in plain words
Oliceridine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Tolterodine belongs to Genitourinary.
Why it happens
Additive reduction of gastrointestinal and bladder smooth muscle activity through opioid and muscarinic receptor effects.
What to do
Monitor for constipation and urinary retention and use a prophylactic bowel regimen. Reduce or stop tolterodine if retention or reduced motility occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Tolterodine?
MediHelp rates the interaction as moderate. Oliceridine and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids slow gut motility and can cause urinary retention, and anticholinergic drugs share these effects. Together they increase the risk of severe constipation, urinary retention and paralytic ileus.
How serious is the interaction between Oliceridine and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation and urinary retention and use a prophylactic bowel regimen. Reduce or stop tolterodine if retention or reduced motility occurs.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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