Drug interactions
Olmesartan + Trofinetide
Severity: Moderate
Olmesartan and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide may inhibit OATP1B1/1B3 and raise exposure to substrates such as olmesartan. The increase is probably modest, with possible hypotension or renal effects.
What this interaction means in plain words
Olmesartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olmesartan belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Possible inhibition of hepatic OATP1B1/1B3 uptake by trofinetide, raising olmesartan levels.
What to do
Monitor blood pressure and renal function when combining them. Reduce the olmesartan dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Olmesartan with Trofinetide?
MediHelp rates the interaction as moderate. Olmesartan and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide may inhibit OATP1B1/1B3 and raise exposure to substrates such as olmesartan. The increase is probably modest, with possible hypotension or renal effects.
How serious is the interaction between Olmesartan and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when combining them. Reduce the olmesartan dose if hypotension develops.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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