Drug interactions
Olodaterol inhaled + Perphenazine
Severity: Moderate
Olodaterol inhaled and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olodaterol, a long-acting beta2 agonist, can cause tachycardia, hypokalemia and QT prolongation, and perphenazine also has QT-prolonging potential. Together they may increase the risk of ventricular arrhythmias, particularly in patients with other risk factors. The systemic exposure from inhalation is low, but caution remains relevant.
What this interaction means in plain words
Olodaterol inhaled and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta2-agonist-induced hypokalemia and sympathetic stimulation increasing arrhythmic susceptibility.
What to do
Check baseline ECG and potassium and magnesium levels in patients with cardiac risk factors. Correct electrolyte disturbances and monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Olodaterol inhaled with Perphenazine?
MediHelp rates the interaction as moderate. Olodaterol inhaled and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olodaterol, a long-acting beta2 agonist, can cause tachycardia, hypokalemia and QT prolongation, and perphenazine also has QT-prolonging potential. Together they may increase the risk of ventricular arrhythmias, particularly in patients with other risk factors. The systemic exposure from inhalation is low, but caution remains relevant.
How serious is the interaction between Olodaterol inhaled and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and potassium and magnesium levels in patients with cardiac risk factors. Correct electrolyte disturbances and monitor for palpitations or syncope.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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