Drug interactions
Olodaterol inhaled + Tacrolimus
Severity: Moderate
Olodaterol inhaled and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can prolong the QT interval and beta2-agonists can affect heart rhythm and potassium. Together they may modestly raise the risk of arrhythmia, particularly with electrolyte disturbances.
What this interaction means in plain words
Olodaterol inhaled and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and beta2-mediated hypokalemia.
What to do
Correct potassium and magnesium abnormalities and consider ECG monitoring in patients with other QT risk factors or heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Olodaterol inhaled with Tacrolimus?
MediHelp rates the interaction as moderate. Olodaterol inhaled and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can prolong the QT interval and beta2-agonists can affect heart rhythm and potassium. Together they may modestly raise the risk of arrhythmia, particularly with electrolyte disturbances.
How serious is the interaction between Olodaterol inhaled and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium abnormalities and consider ECG monitoring in patients with other QT risk factors or heart disease.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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