Drug interactions
Olutasidenib + Quinidine
Severity: Major
Olutasidenib and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4, which is the main route of quinidine clearance. Quinidine exposure may fall, leading to loss of antiarrhythmic or antimalarial effect.
What this interaction means in plain words
Olutasidenib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olutasidenib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Olutasidenib induces CYP3A4, increasing the hepatic and intestinal metabolism of quinidine.
What to do
Avoid the combination where possible. If it cannot be avoided, monitor quinidine concentrations and ECG and adjust the quinidine dose for loss of effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Olutasidenib with Quinidine?
MediHelp rates the interaction as major. Olutasidenib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olutasidenib induces CYP3A4, which is the main route of quinidine clearance. Quinidine exposure may fall, leading to loss of antiarrhythmic or antimalarial effect.
How serious is the interaction between Olutasidenib and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it cannot be avoided, monitor quinidine concentrations and ECG and adjust the quinidine dose for loss of effect.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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