Drug interactions
Omadacycline + Piperacillin-tazobactam
Severity: Moderate
Omadacycline and Piperacillin-tazobactam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omadacycline is bacteriostatic and could in theory reduce the bactericidal activity of piperacillin. Clinical evidence of poorer outcomes is limited. It is of most concern in severe infections.
What this interaction means in plain words
Omadacycline and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omadacycline belongs to Anti Bacterial; Piperacillin-tazobactam belongs to Anti Bacterial.
Why it happens
Pharmacodynamic antagonism: growth inhibition by a protein synthesis inhibitor reduces beta-lactam killing.
What to do
Avoid combination in severe infections unless dual therapy is required. Monitor clinical response if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piperacillin-tazobactam
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Omadacycline with Piperacillin-tazobactam?
MediHelp rates the interaction as moderate. Omadacycline and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omadacycline is bacteriostatic and could in theory reduce the bactericidal activity of piperacillin. Clinical evidence of poorer outcomes is limited. It is of most concern in severe infections.
How serious is the interaction between Omadacycline and Piperacillin-tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination in severe infections unless dual therapy is required. Monitor clinical response if used together.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
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