Drug interactions
Omadacycline + Selenium
Severity: Minor
Omadacycline and Selenium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines bind polyvalent cations in the gut, reducing absorption. Selenium is not a classic chelating cation, so any reduction in omadacycline exposure is theoretical but could weaken antibacterial efficacy.
What this interaction means in plain words
Omadacycline and Selenium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omadacycline belongs to Anti Bacterial; Selenium belongs to Gastrointestinal Tract.
Why it happens
Possible chelation of omadacycline by mineral supplements in the gastrointestinal tract.
What to do
Separate oral omadacycline from selenium-containing mineral supplements by at least 4 hours.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Selenium
- Alendronate + Selenium Moderate
- Eltrombopag + Selenium Moderate
- Ibandronate + Selenium Moderate
- Penicillamine + Selenium Moderate
- Risedronate + Selenium Moderate
- Baloxavir marboxil + Selenium Minor
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Omadacycline with Selenium?
MediHelp rates the interaction as minor. Omadacycline and Selenium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tetracyclines bind polyvalent cations in the gut, reducing absorption. Selenium is not a classic chelating cation, so any reduction in omadacycline exposure is theoretical but could weaken antibacterial efficacy.
How serious is the interaction between Omadacycline and Selenium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral omadacycline from selenium-containing mineral supplements by at least 4 hours.
What other medicines interact with Selenium?
MediHelp also lists interactions of Selenium with, for example, Alendronate, Eltrombopag, Ibandronate. The full list is on the Selenium page.
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