Drug interactions
Omadacycline + Vitamin B6
Severity: Minor
Omadacycline and Vitamin B6: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pyridoxine itself is not a multivalent cation, so a chelation interaction with omadacycline is not expected. Any effect would come only from multivitamin or mineral products that also contain cations, which can reduce oral omadacycline absorption.
What this interaction means in plain words
Omadacycline and Vitamin B6 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omadacycline belongs to Anti Bacterial; Vitamin B6 belongs to Gastrointestinal Tract.
Why it happens
Chelation by multivalent cations in combination products may reduce tetracycline absorption; pyridoxine alone has no established effect.
What to do
Pyridoxine alone needs no separation. If a combined supplement contains minerals such as calcium, iron, magnesium or zinc, give oral omadacycline at least 4 hours before or after it, per labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin B6
- Ethotoin + Vitamin B6 Moderate
- Fosphenytoin + Vitamin B6 Moderate
- Isoniazid + Vitamin B6 Moderate
- Levodopa + Vitamin B6 Moderate
- Penicillamine + Vitamin B6 Moderate
- Phenobarbital + Vitamin B6 Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Omadacycline with Vitamin B6?
MediHelp rates the interaction as minor. Omadacycline and Vitamin B6 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pyridoxine itself is not a multivalent cation, so a chelation interaction with omadacycline is not expected. Any effect would come only from multivitamin or mineral products that also contain cations, which can reduce oral omadacycline absorption.
How serious is the interaction between Omadacycline and Vitamin B6?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Pyridoxine alone needs no separation. If a combined supplement contains minerals such as calcium, iron, magnesium or zinc, give oral omadacycline at least 4 hours before or after it, per labeling.
What other medicines interact with Vitamin B6?
MediHelp also lists interactions of Vitamin B6 with, for example, Ethotoin, Fosphenytoin, Isoniazid. The full list is on the Vitamin B6 page.
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