Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Omeprazole
Severity: Moderate
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-containing regimens can reduce omeprazole exposure through enzyme induction, weakening acid suppression.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP2C19 by ritonavir-containing regimen increases omeprazole clearance.
What to do
Monitor for decreased omeprazole efficacy and increase the dose if symptoms are poorly controlled, not exceeding 40 mg daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Omeprazole?
MediHelp rates the interaction as moderate. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-containing regimens can reduce omeprazole exposure through enzyme induction, weakening acid suppression.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for decreased omeprazole efficacy and increase the dose if symptoms are poorly controlled, not exceeding 40 mg daily.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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