Drug interactions
Ombitasvir / paritaprevir / ritonavir and dasabuvir + Rimegepant
Severity: Major
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Rimegepant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen contains ritonavir, a strong CYP3A4 and P-glycoprotein inhibitor, and can markedly raise rimegepant exposure. Adverse effects of rimegepant may increase.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and dasabuvir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir-mediated inhibition of CYP3A4 and P-glycoprotein.
What to do
Avoid concomitant use and select an alternative acute migraine therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir and dasabuvir with Rimegepant?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and dasabuvir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. This regimen contains ritonavir, a strong CYP3A4 and P-glycoprotein inhibitor, and can markedly raise rimegepant exposure. Adverse effects of rimegepant may increase.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and dasabuvir and Rimegepant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and select an alternative acute migraine therapy.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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