Drug interactions
Ombitasvir / paritaprevir / ritonavir + Ribociclib
Severity: Major
Ombitasvir / paritaprevir / ritonavir and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib exposure rises markedly with ritonavir, a strong CYP3A4 inhibitor, and both agents prolong the QT interval. This increases the risk of ribociclib toxicity and arrhythmia.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir and paritaprevir inhibit CYP3A4 and raise ribociclib levels, with additive QT prolongation.
What to do
Avoid if possible. If unavoidable, reduce the ribociclib dose per labeling and monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir with Ribociclib?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib exposure rises markedly with ritonavir, a strong CYP3A4 inhibitor, and both agents prolong the QT interval. This increases the risk of ribociclib toxicity and arrhythmia.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, reduce the ribociclib dose per labeling and monitor ECG and electrolytes.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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