Drug interactions
Ombitasvir / paritaprevir / ritonavir + Voriconazole
Severity: Major
Ombitasvir / paritaprevir / ritonavir and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise paritaprevir and ritonavir concentrations, while ritonavir may lower voriconazole exposure. The result is uncertain exposure with risk of both toxicity and antifungal failure.
What this interaction means in plain words
Ombitasvir / paritaprevir / ritonavir and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of paritaprevir and ritonavir, whereas ritonavir induces CYP2C19 clearance of voriconazole.
What to do
Avoid unless benefit clearly outweighs risk; if used, monitor voriconazole trough levels, liver function and for hepatitis C regimen adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ombitasvir / paritaprevir / ritonavir with Voriconazole?
MediHelp rates the interaction as major. Ombitasvir / paritaprevir / ritonavir and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole may raise paritaprevir and ritonavir concentrations, while ritonavir may lower voriconazole exposure. The result is uncertain exposure with risk of both toxicity and antifungal failure.
How serious is the interaction between Ombitasvir / paritaprevir / ritonavir and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless benefit clearly outweighs risk; if used, monitor voriconazole trough levels, liver function and for hepatitis C regimen adverse effects.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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