Drug interactions
Omeprazole + Pentobarbital
Severity: Moderate
Omeprazole and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital is an enzyme inducer and may lower omeprazole exposure. Acid suppression may be weaker than expected, which matters for patients treated for ulcers, reflux or Helicobacter pylori eradication.
What this interaction means in plain words
Omeprazole and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP2C19 and CYP3A4 increases the hepatic metabolism of omeprazole.
What to do
Monitor for loss of symptom control and consider a higher omeprazole dose or a different acid-suppressing agent if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Omeprazole with Pentobarbital?
MediHelp rates the interaction as moderate. Omeprazole and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital is an enzyme inducer and may lower omeprazole exposure. Acid suppression may be weaker than expected, which matters for patients treated for ulcers, reflux or Helicobacter pylori eradication.
How serious is the interaction between Omeprazole and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of symptom control and consider a higher omeprazole dose or a different acid-suppressing agent if response is inadequate.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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