Drug interactions
Omeprazole + Ponatinib
Severity: Minor
Omeprazole and Ponatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib solubility falls as pH rises, so acid suppression may lower its exposure. Studies with a PPI showed no clinically important change in ponatinib exposure.
What this interaction means in plain words
Omeprazole and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Ponatinib belongs to Oncology.
Why it happens
Elevated gastric pH may reduce ponatinib dissolution.
What to do
No dose adjustment is required; monitor hematologic and molecular response as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Omeprazole with Ponatinib?
MediHelp rates the interaction as minor. Omeprazole and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponatinib solubility falls as pH rises, so acid suppression may lower its exposure. Studies with a PPI showed no clinically important change in ponatinib exposure.
How serious is the interaction between Omeprazole and Ponatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor hematologic and molecular response as usual.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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