Drug interactions
Omeprazole + Quazepam
Severity: Minor
Omeprazole and Quazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole may raise quazepam levels, increasing sedation and psychomotor impairment. The effect is typically modest.
What this interaction means in plain words
Omeprazole and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Omeprazole inhibits CYP2C19 and possibly CYP3A4-mediated quazepam metabolism.
What to do
Monitor for excessive sedation, especially in older adults, and reduce the quazepam dose if it occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Omeprazole with Quazepam?
MediHelp rates the interaction as minor. Omeprazole and Quazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole may raise quazepam levels, increasing sedation and psychomotor impairment. The effect is typically modest.
How serious is the interaction between Omeprazole and Quazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, especially in older adults, and reduce the quazepam dose if it occurs.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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