Drug interactions
Omeprazole + Rifampin
Severity: Moderate
Omeprazole and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin is a potent inducer of CYP2C19 and CYP3A4 and markedly lowers omeprazole exposure. Therapeutic acid suppression may be lost.
What this interaction means in plain words
Omeprazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP2C19 and CYP3A4, increasing omeprazole clearance.
What to do
Monitor symptoms and consider a higher omeprazole dose or a less affected acid suppressant. Reassess the dose after rifampin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Omeprazole with Rifampin?
MediHelp rates the interaction as moderate. Omeprazole and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin is a potent inducer of CYP2C19 and CYP3A4 and markedly lowers omeprazole exposure. Therapeutic acid suppression may be lost.
How serious is the interaction between Omeprazole and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptoms and consider a higher omeprazole dose or a less affected acid suppressant. Reassess the dose after rifampin is stopped.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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