Drug interactions
Omeprazole + Secretin
Severity: Moderate
Omeprazole and Secretin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Proton pump inhibitor therapy raises baseline gastrin and can exaggerate the gastrin response during secretin stimulation testing. This can produce a false-positive result that wrongly suggests a gastrinoma.
What this interaction means in plain words
Omeprazole and Secretin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Acid suppression causes hypergastrinemia, and this exaggerated gastrin response confounds the interpretation of the secretin stimulation test.
What to do
If clinically feasible, withhold omeprazole for at least 14 days before secretin stimulation testing, with gastric acid control covered by an alternative under medical supervision. Interpret results cautiously if the PPI cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Omeprazole and Secretin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Omeprazole with Secretin?
MediHelp rates the interaction as moderate. Omeprazole and Secretin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Proton pump inhibitor therapy raises baseline gastrin and can exaggerate the gastrin response during secretin stimulation testing. This can produce a false-positive result that wrongly suggests a gastrinoma.
How serious is the interaction between Omeprazole and Secretin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If clinically feasible, withhold omeprazole for at least 14 days before secretin stimulation testing, with gastric acid control covered by an alternative under medical supervision. Interpret results cautiously if the PPI cannot be stopped.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
