Drug interactions
Omeprazole + Theophylline
Severity: Minor
Omeprazole and Theophylline: minor interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole has little effect on theophylline in most patients, though small changes in clearance have been reported. Clinically meaningful toxicity is unusual.
What this interaction means in plain words
Omeprazole and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Theophylline belongs to Respiratory.
Why it happens
Omeprazole may weakly alter CYP1A2-mediated theophylline metabolism, but the mechanism is not firmly established.
What to do
No routine dose change is needed; check theophylline levels if signs of toxicity such as nausea, tremor or tachycardia appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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References
- Theophylline (Anhydrous) - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Omeprazole with Theophylline?
MediHelp rates the interaction as minor. Omeprazole and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole has little effect on theophylline in most patients, though small changes in clearance have been reported. Clinically meaningful toxicity is unusual.
How serious is the interaction between Omeprazole and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; check theophylline levels if signs of toxicity such as nausea, tremor or tachycardia appear.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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