Drug interactions
Omeprazole + Tofacitinib
Severity: Minor
Omeprazole and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole inhibits CYP2C19, a minor route of tofacitinib clearance, which may modestly raise tofacitinib exposure. The effect is generally small unless combined with a moderate CYP3A4 inhibitor.
What this interaction means in plain words
Omeprazole and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Tofacitinib belongs to Musculoskeletal.
Why it happens
Omeprazole inhibits CYP2C19 metabolism of tofacitinib.
What to do
No adjustment is generally needed, but reduce the tofacitinib dose if the patient also takes a moderate CYP3A4 inhibitor. Monitor for infections and cytopenias.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Omeprazole with Tofacitinib?
MediHelp rates the interaction as minor. Omeprazole and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole inhibits CYP2C19, a minor route of tofacitinib clearance, which may modestly raise tofacitinib exposure. The effect is generally small unless combined with a moderate CYP3A4 inhibitor.
How serious is the interaction between Omeprazole and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally needed, but reduce the tofacitinib dose if the patient also takes a moderate CYP3A4 inhibitor. Monitor for infections and cytopenias.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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