Drug interactions
Omeprazole + Triazolam
Severity: Minor
Omeprazole and Triazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole may modestly increase triazolam exposure, leading to greater sedation or impaired psychomotor performance. Triazolam is mainly cleared by CYP3A4, so the effect is usually small.
What this interaction means in plain words
Omeprazole and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Omeprazole may weakly inhibit CYP3A4 and CYP2C19-mediated metabolism of triazolam.
What to do
Monitor for increased drowsiness and lower the triazolam dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Omeprazole with Triazolam?
MediHelp rates the interaction as minor. Omeprazole and Triazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole may modestly increase triazolam exposure, leading to greater sedation or impaired psychomotor performance. Triazolam is mainly cleared by CYP3A4, so the effect is usually small.
How serious is the interaction between Omeprazole and Triazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased drowsiness and lower the triazolam dose if excessive sedation occurs.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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