Drug interactions
OnabotulinumtoxinA + Pimozide
Severity: Minor
OnabotulinumtoxinA and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs with anticholinergic properties may increase the neuromuscular weakness from botulinum toxin. Pimozide has modest anticholinergic activity, so the effect is likely small, but generalised weakness or anticholinergic effects are possible.
What this interaction means in plain words
OnabotulinumtoxinA and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
OnabotulinumtoxinA belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive interference with cholinergic neuromuscular transmission, a theoretical effect.
What to do
Monitor for excessive or distant muscle weakness, swallowing difficulty, and anticholinergic effects after injection. Use the lowest effective toxin dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of OnabotulinumtoxinA
Frequently asked questions
Can I take OnabotulinumtoxinA with Pimozide?
MediHelp rates the interaction as minor. OnabotulinumtoxinA and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drugs with anticholinergic properties may increase the neuromuscular weakness from botulinum toxin. Pimozide has modest anticholinergic activity, so the effect is likely small, but generalised weakness or anticholinergic effects are possible.
How serious is the interaction between OnabotulinumtoxinA and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive or distant muscle weakness, swallowing difficulty, and anticholinergic effects after injection. Use the lowest effective toxin dose.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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