Drug interactions
Albuterol + Ondansetron
Severity: Minor
Albuterol and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron prolongs the QT interval, and albuterol can cause hypokalemia, tachycardia and a small QT effect, especially at high or nebulized doses. Together they may increase the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Albuterol and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive QT effect, with albuterol-induced hypokalemia and beta-adrenergic stimulation adding to the risk.
What to do
No routine action is needed at usual doses. Check potassium and consider an ECG in patients receiving high-dose beta-agonists or with underlying cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Albuterol with Ondansetron?
MediHelp rates the interaction as minor. Albuterol and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ondansetron prolongs the QT interval, and albuterol can cause hypokalemia, tachycardia and a small QT effect, especially at high or nebulized doses. Together they may increase the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Albuterol and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed at usual doses. Check potassium and consider an ECG in patients receiving high-dose beta-agonists or with underlying cardiac disease.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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