Drug interactions
Ondansetron + Vandetanib
Severity: Contraindicated
Ondansetron and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib has a boxed warning for QT prolongation, torsades de pointes and sudden death. Ondansetron adds to the QT effect and the combination should be avoided.
What this interaction means in plain words
Ondansetron and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ondansetron belongs to Gastrointestinal Tract; Vandetanib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination and use an antiemetic without QT effect. Vandetanib labeling advises against concomitant QT-prolonging drugs.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
- Amoxapine + Ondansetron Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Ondansetron with Vandetanib?
MediHelp rates the interaction as contraindicated. Ondansetron and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib has a boxed warning for QT prolongation, torsades de pointes and sudden death. Ondansetron adds to the QT effect and the combination should be avoided.
How serious is the interaction between Ondansetron and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiemetic without QT effect. Vandetanib labeling advises against concomitant QT-prolonging drugs.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Adagrasib. The full list is on the Ondansetron page.
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