Drug reference
ondansetron
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (5-HT3 Antagonist)
Mechanism of action
Mechanism not fully characterized; selective 5-HT3 receptor antagonist; binds to 5-HT3 receptors both in periphery and in CNS, with primary effects in GI tract. Has no effect on dopamine receptors and therefore does not cause extrapyramidal symptoms.
Common side effects
- Malaise/fatigue
- Constipation
- Drowsiness
- Headache
- Hypoxia
Contraindications
- Coadministration with apomorphine; combination reported to cause profound hypotension and loss of consciousness
Known interactions (10)
- amiodarone + ondansetron Major
- dronedarone + ondansetron Major
- levofloxacin + ondansetron Major
- methadone + ondansetron Major
- ondansetron + voriconazole Major
- acetazolamide + ondansetron Moderate
- dexlansoprazole + ondansetron Moderate
- Fluoxetine + ondansetron Moderate
- Olanzapine + ondansetron Moderate
- ondansetron + Oxcarbazepine Moderate
Related conditions
Frequently asked questions
What drug class is ondansetron?
ondansetron belongs to: Gastrointestinal Tract.
How does ondansetron work?
Mechanism not fully characterized; selective 5-HT3 receptor antagonist; binds to 5-HT3 receptors both in periphery and in CNS, with primary effects in GI tract. Has no effect on dopamine receptors and therefore does not cause extrapyramidal symptoms.
What are the common side effects of ondansetron?
Malaise/fatigue, Constipation, Drowsiness, Headache, Hypoxia
Which drugs interact with ondansetron?
amiodarone, dronedarone, levofloxacin, methadone, voriconazole, acetazolamide, dexlansoprazole, Fluoxetine, Olanzapine, Oxcarbazepine
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