Drug interactions
Apomorphine + Ondansetron
Severity: Contraindicated
Apomorphine and Ondansetron: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Profound hypotension and loss of consciousness have been reported when ondansetron is given with apomorphine. Both can also prolong the QT interval.
What this interaction means in plain words
Apomorphine and Ondansetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apomorphine belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Mechanism of the hypotension is not established; additive QT prolongation is also possible.
What to do
Do not combine. Use a non-5-HT3 antiemetic such as domperidone or trimethobenzamide with apomorphine, according to local availability.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ondansetron
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
- Amoxapine + Ondansetron Major
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Palonosetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Ondansetron?
MediHelp rates the interaction as contraindicated. Apomorphine and Ondansetron are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Profound hypotension and loss of consciousness have been reported when ondansetron is given with apomorphine. Both can also prolong the QT interval.
How serious is the interaction between Apomorphine and Ondansetron?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use a non-5-HT3 antiemetic such as domperidone or trimethobenzamide with apomorphine, according to local availability.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Thioridazine, Vandetanib, Adagrasib. The full list is on the Ondansetron page.
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