Drug interactions
Opium tincture + Paliperidone
Severity: Moderate
Opium tincture and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture contains morphine and other opioid alkaloids, so with paliperidone it can cause additive sedation, hypotension and respiratory depression.
What this interaction means in plain words
Opium tincture and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedative effects.
What to do
Use the lowest effective opioid dose and monitor for sedation, breathing and blood pressure. Warn against alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Opium tincture with Paliperidone?
MediHelp rates the interaction as moderate. Opium tincture and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opium tincture contains morphine and other opioid alkaloids, so with paliperidone it can cause additive sedation, hypotension and respiratory depression.
How serious is the interaction between Opium tincture and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor for sedation, breathing and blood pressure. Warn against alcohol and other sedatives.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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