Drug interactions
Orlistat + Paricalcitol
Severity: Minor
Orlistat and Paricalcitol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat reduces absorption of dietary fat and fat-soluble vitamins, and may similarly reduce absorption of the fat-soluble vitamin D analog paricalcitol. This could lessen its effect on parathyroid hormone suppression.
What this interaction means in plain words
Orlistat and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Orlistat belongs to Miscellaneous; Paricalcitol belongs to Musculoskeletal.
Why it happens
Orlistat inhibits gastrointestinal lipases and reduces absorption of lipophilic compounds.
What to do
Separate doses by at least 2 hours and monitor intact PTH, calcium and phosphorus.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Other interactions of Paricalcitol
- Carbamazepine + Paricalcitol Moderate
- Cholestyramine + Paricalcitol Moderate
- Clarithromycin + Paricalcitol Moderate
- Digoxin + Paricalcitol Moderate
- Ketoconazole + Paricalcitol Moderate
- Paricalcitol + Posaconazole Moderate
Frequently asked questions
Can I take Orlistat with Paricalcitol?
MediHelp rates the interaction as minor. Orlistat and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orlistat reduces absorption of dietary fat and fat-soluble vitamins, and may similarly reduce absorption of the fat-soluble vitamin D analog paricalcitol. This could lessen its effect on parathyroid hormone suppression.
How serious is the interaction between Orlistat and Paricalcitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours and monitor intact PTH, calcium and phosphorus.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporine, Cyclosporin, Triheptanoin. The full list is on the Orlistat page.
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