Drug interactions
Orlistat + Tiratricol
Severity: Moderate
Orlistat and Tiratricol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat reduces fat absorption and has been linked to reduced absorption of levothyroxine, with hypothyroidism reported. Lipophilic tiratricol could be similarly affected.
What this interaction means in plain words
Orlistat and Tiratricol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orlistat belongs to Miscellaneous; Tiratricol belongs to Endocrine.
Why it happens
Orlistat may reduce intestinal absorption of lipophilic thyroid hormone analogues; the mechanism is not fully defined.
What to do
Separate dosing by at least 4 hours and monitor thyroid function, adjusting the tiratricol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiratricol
- Levothyroxine + Tiratricol Major
- Calcium + Tiratricol Moderate
- Carbamazepine + Tiratricol Moderate
- Carbimazole + Tiratricol Moderate
- Charcoal + Tiratricol Moderate
- Chloroquine + Tiratricol Moderate
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Orlistat with Tiratricol?
MediHelp rates the interaction as moderate. Orlistat and Tiratricol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orlistat reduces fat absorption and has been linked to reduced absorption of levothyroxine, with hypothyroidism reported. Lipophilic tiratricol could be similarly affected.
How serious is the interaction between Orlistat and Tiratricol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dosing by at least 4 hours and monitor thyroid function, adjusting the tiratricol dose if needed.
What other medicines interact with Tiratricol?
MediHelp also lists interactions of Tiratricol with, for example, Levothyroxine, Calcium, Carbamazepine. The full list is on the Tiratricol page.
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