Drug interactions
Orlistat + Tolazamide
Severity: Minor
Orlistat and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat-associated weight loss and reduced fat intake can improve glycemic control, which may increase the glucose-lowering effect of tolazamide. Hypoglycemia is possible as weight falls.
What this interaction means in plain words
Orlistat and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Orlistat belongs to Miscellaneous; Tolazamide belongs to Endocrine.
Why it happens
Improved glycemic control from weight loss and reduced caloric absorption adds to sulfonylurea effect; no direct pharmacokinetic interaction is established.
What to do
Monitor blood glucose after starting orlistat and reduce the tolazamide dose if glucose levels fall.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Frequently asked questions
Can I take Orlistat with Tolazamide?
MediHelp rates the interaction as minor. Orlistat and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orlistat-associated weight loss and reduced fat intake can improve glycemic control, which may increase the glucose-lowering effect of tolazamide. Hypoglycemia is possible as weight falls.
How serious is the interaction between Orlistat and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting orlistat and reduce the tolazamide dose if glucose levels fall.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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