Drug interactions
Orlistat + Vitamin e
Severity: Minor
Orlistat and Vitamin e: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orlistat reduces dietary fat absorption and with it the absorption of fat-soluble vitamins, including vitamin E. Long-term use may lower vitamin E levels.
What this interaction means in plain words
Orlistat and Vitamin e have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Orlistat belongs to Miscellaneous; Vitamin e belongs to Gastrointestinal Tract.
Why it happens
Inhibition of gastrointestinal lipase reduces absorption of fat-soluble vitamins.
What to do
Take a multivitamin containing vitamin E at least 2 hours before or after orlistat, such as at bedtime. Monitor nutritional status during long-term therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Other interactions of Vitamin e
- Betrixaban + Vitamin e Moderate
- Phenindione + Vitamin e Moderate
- Selumetinib + Vitamin e Moderate
- Vitamin e + Warfarin Moderate
- Alfalfa + Vitamin e Minor
- Antithrombin alfa + Vitamin e Minor
Frequently asked questions
Can I take Orlistat with Vitamin e?
MediHelp rates the interaction as minor. Orlistat and Vitamin e have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Orlistat reduces dietary fat absorption and with it the absorption of fat-soluble vitamins, including vitamin E. Long-term use may lower vitamin E levels.
How serious is the interaction between Orlistat and Vitamin e?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take a multivitamin containing vitamin E at least 2 hours before or after orlistat, such as at bedtime. Monitor nutritional status during long-term therapy.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporine, Cyclosporin, Triheptanoin. The full list is on the Orlistat page.
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