Drug interactions
Orphenadrin + Scopolamine
Severity: Moderate
Orphenadrin and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combined use increases anticholinergic effects. Patients may develop dry mouth, blurred vision, urinary retention, constipation, tachycardia, confusion or delirium, especially if elderly.
What this interaction means in plain words
Orphenadrin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid the combination in older patients or those with glaucoma, urinary retention or cognitive impairment. Otherwise monitor for anticholinergic toxicity and reduce doses if it occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Orphenadrin and Scopolamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Orphenadrin
Other interactions of Scopolamine
Frequently asked questions
Can I take Orphenadrin with Scopolamine?
MediHelp rates the interaction as moderate. Orphenadrin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combined use increases anticholinergic effects. Patients may develop dry mouth, blurred vision, urinary retention, constipation, tachycardia, confusion or delirium, especially if elderly.
How serious is the interaction between Orphenadrin and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients or those with glaucoma, urinary retention or cognitive impairment. Otherwise monitor for anticholinergic toxicity and reduce doses if it occurs.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
